cIAP1 E3 ligase inhibitor D19

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

cIAP1 E3 连接酶抑制剂 D19 (cIAP1抑制剂D19)是cIAP1 E3连接酶活性的小分子抑制剂，抑制cIAP1自动泛素化，IC50为14.1 uM。

cIAP1 E3 ligase inhibitor D19 (cIAP1 inhibitor D19) is a small-molecule inhibitor of E3 ligase activity of cIAP1, inhibits cIAP1 auto-ubiquitination with IC50 of 14.1 uM, shows no effect on autoubiquitination of BRCA1/BARD1; binds to the RING domain of cIAP1 and inhibits the E3 ligase activity of cIAP1 by interfering with the dynamics of its interaction with E2, inhibited cIAP1 autoubiquitination with all of the E2s (t UbcH5a/b/c, UbcH6, and Ubc13/Uev1a) that can mediate its activity; suppresses c-MYC oncogenic function and cancer cell proliferation by stabilizing MAD1 protein and promoting the degradation of c-MYC.

——

——

cIAP1 inhibitor D19

Proteasome/Ubiquitin

E3 Ubiquitin Ligase

E3 Ubiquitin Ligase

——

——

380640-76-6

325.404

C16H11N3OS2

>98% (HPLC)

——

OC1=C(/C=N/NC2=NC3=CC=CC=C3S2)SC4=CC=CC=C41

(E)-2-((2-(benzo[d]thiazol-2-yl)hydrazono)methyl)benzo[b]thiophen-3-ol

(-20℃)

With Ice Pack

≥ 2 years